Ai-Ling Lin1, Jia-Hong Gao2,
Timothy Q. Duong1, Peter T. Fox1
1Research Imaging Institute, University
of Texas Health Science Center at San Antonio, San Antonio, TX, United
States; 2Brain Research Imaging Center, University of Chicago,
Chicago, IL, United States
The
purpose of the study was to investigate the contributions of oxidative verses
non-oxidative metabolism to (1) ATP (energy) production (JATP);
and (2) cerebral blood flow (CBF) augmentation, during neuronal activation.
Cerebral oxygen metabolic rate, blood flow and lactate concentration were
determined using concurrent fMRI and 1H MRS with visual
stimulations at different flickering frequencies. Our results provide
additional supportive evidences that (1)the energy demand for brain
activations is small and is met through oxidative metabolism; and (2) CBF can
be regulated by non-oxidative glycolysis, rather than by oxygen demand.