Maria A. Schmidt1, Geoffrey S. Payne1,
Veronica A. Morgan1, Sharon Giles1, Jane Bridges2,
Thomas Ind2, Nandita deSouza1
1CRUK/ESPRC Cancer Imaging Centre,
Institute of Cancer Research and Royal Marsden NHS Foundation Trust, MRI Unit
, Sutton, England, United Kingdom; 2Gynaecological Oncology, Royal
Marsden NHS Foundation Trust and Chelsea & Westminster Hospital, London,
United Kingdom
This
study applies functional MRI techniques (DWI and MRS) to cervical tumors with
different histological characteristics (type, degree of differentiation and
presence or absence of lymphovascular invasion) in order to investigate their
potential as predictive biomarkers. There was a statistically significant
difference between the ADC of well/moderately differentiated tumors compared
with poorly differentiated tumors. There was no significant difference
between the ADCs of the tumors when separated by other characteristics. There
was no significant difference in tCho between any of the tumor categories
investigated and no correlation between tumor ADC and tCho.