Ashley D. Harris1, Richard A. E. Edden2,3,
Kevin Murphy1, C John Evans1, Chen Y. Poon4,
Neeraj Saxena5, Judith Hall5, Thomas T. Liu6,
Damian M. Bailey7, Richard G. Wise1
1Cardiff University Brain Research
Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom; 2Russell
H Morgan Department of Radiology and Radiological Science, The Johns Hopkins
University, Baltimore, MD, United States; 3Cardiff University
Brain Imaging Research Centre (CUBRIC) and Schools of Chemistry and
Biosciences, Cardiff University, Cardiff, United Kingdom; 4School
of Medicine, Cardiff University, Cardiff, United Kingdom; 5Anaesthetics
and Intensive Care Medicine, Cardiff University, Cardiff, United Kingdom; 6Center
for Functional MRI (fMRI), University of California, San Diego, San Diego,
CA, United States; 7Health, Sport and Science, University of
Glamorgan, Mid-Glamorgan, United Kingdom
MR
spectroscopy to examine lactate and ASL perfusion imaging are used to study
the response to 12% hypoxia in healthy subjects. Lactate and cerebral blood
flow increased during hypoxia. Both lactate and blood flow are negatively
related to oxygen saturation. The relationship between increased perfusion
and lactate accumulation appears to be more complex; however, by
understanding these relationships, we may gain insight into cerebral
pathologies and conditions that result in hypoxemia.