Effects of Smoking on Mouse Adipose Tissue Volumes Measured by IDEAL at 11.7T

David Johnson¹, Jiarui Lian¹, Mohamed El-Mahdy¹, Jay L. Zweier¹

An imaging technique was developed to produce uniform, robust fat-water separation in mice at 11.7T using Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation method (IDEAL). Cigarette smoking (CS) C57BL/6 mice had less body weight and subcutaneous adipose tissue volumes as compared to controls. The volumes of muscle and other non-adipose tissues were not different between CS and control mice, supporting the hypothesis of a selective reduction in fat storage due to smoking.