Rebecca Sara Samson1, Sean C L Deoni2, Claudia A M Wheeler-Kingshott1
1Department of Neuroinflammation, UCL Institute of Neurology, London, UK; 2Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
It has previously been suggested that both the restricted proton fraction (fb) measured from quantitative Magnetisation Transfer (qMT) and myelin water fraction (fm) from multi-component relaxometry are related to myelin content in the brain. Multi-Component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) is a promising alternative to spin-echo multi-component T2 analysis. This pilot study investigates the correlation of fm measured via the mcDESPOT technique with fb at 1.5T in white and grey matter in three healthy volunteers.