Rafael Luis O'Halloran1, James H. Holmes1,2, Eric T. Peterson3, Ronald L. Sorkness4, Mark L. Schiebler5, Sean B. Fain1,5
1Medical Physics, University of Wisconsin, Madison, WI, USA; 2Applied Science Laboratory, GE Healthcare, Waukesha, WI, USA; 3Biomedical Engineering, University of Wisconsin, Madison, WI, USA; 4School of Pharmacy, University of Wisconsin, Madison, WI, USA; 5Radiology, University of Wisconsin, Madison, WI, USA
Dynamic hyperpolarized He-3 imaging of the lung using 2D radial acquisition and Iterative HYPR reconstruction is performed in healthy volunteers. The combination of highly undersampled radial acquisition and iterative reconstruction provides a temporal resolution of 20 ms or 50 frames per second, allowing subtle patterns of differential lung filling to be visualized. Parametric maps are calculated from the time resolved image data.