Rene in 't Zandt1, Magnus Karlsson1, Anna Gisselsson1, Pernille Rose Jensen1, Georg Hansson1, Mathilde Lerche1
1Imagnia AB, Malm, Sweden
We have developed a diagnostic marker - hyperpolarized 1,4-13C2-fumarate, which takes advantage of the technique dynamic nuclear polarization for magnetic resonance imaging (DNP-MRI). This marker allows real-time metabolic studies of a TCA-cycle intermediate, 13C-malate. With this marker we have investigated the metabolism in the liver of CCl4 treated rats.