Michael Simca Middleton1, Gavin Hamilton1, Mark Bydder1, Claude B. Sirlin1
1Radiology, UCSD School of Medicine, San Diego, CA, USA
Accurate MRS liver fat quantitation requires determination of signal from fat peaks that are near or under the water peak. As reported in the literature, the amount of fat in those peaks is determined by fatty acid chain length, number of carbon double bonds, and number of carbon double bonds separated by a single -CH2- group. We validated that we could predict, from the corn oil 0-3 ppm spectrum, the amount of fat that would be under the water peak, and applied that method for in-vivo human liver MRS data to estimate the amount of fat under the water peak.