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Abstract #4304

MRS of Neuronal Progenitor Cells in Vivo

Wolfgang Weber-Fahr1, Jens Benninghoff2, Kai Schnig3, Gabriele Ende4, Sascha Sartorius1

1RG Translational Imaging, Central Institute of Mental Health, Mannheim, Germany; 2Department of Psychiatry and Psychotherapy, University of Munich, Munich, Germany; 3Department of Molecular Biology, Central Institute of Mental Health, Mannheim, Germany; 4Department Neuroimaging, Central Institute of Mental Health, Mannheim, Germany


Lately Manganas et. al used 1H-MRS to investigate neural progenitor cells (NPCs) in vitro and. detected a peak at 1.28 ppm which they did not find in other cultured neural cell types. This study aims to inquire this resonance by measuring the 1H MRS signal of living NPC cell cultures. 18-20 Mio NPCs were measured on a 9.4T animal scanner in growth medium. We could not find a resonance line at 1.28ppm but a triplet at 1.21 ppm which might originate from Ethanol.