Poonam Rana1, Ahmad Raza Khan1, Poonam Singh1, Shubhra Chaturvedi2, Rajendra Prasad Tripathi3, Subash Khushu1
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 3INMAS, Delhi, India
Many NMR based studies have been carried out on liver metabolic status under different chemical or environmental toxic conditions. Our study was planned to find radiation induced changes in hepatic tissue on mice after radiation exposure using 1H NMR spectroscopy. Significant changes were observed after 25 days of exposure in protein/amino acid and energy metabolism and membrane structure alteration as evident from increased branched amino acids, alanine, lysine lactate, choline and myo inositol levels. Such findings support the potential use of metabolomic approach for identification of radiation induced injury in liver.