Xiaoyu Liu1, Gaurav Verma2, Scott Lipnick1, Sasd Ramadan3, Nanette Debruhl1, Michael Albert Thomas1
1Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA; 2Biomedical Energing, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA; 3Harvard Medical School, Boston, MA, USA
Magnetic Resonance Spectroscopy (MRS) studies have detected differences in metabolite concentrations in healthy breast tissues and lesions non-invasively. Two-dimensional (2D) MRS has improved resolution compared to one-dimensional (1D) MRS due to the additional J-coupling information in the second dimension. Single voxel (SV) MRS has limitations in terms of breast coverage. Multi-dimensional MR spectroscopic imaging 2 spatial + 2 spectral solves the problem by generating different metabolic images. In this study we demonstrate the feasibility of evaluating a 4-echo based Turbo-Spin-Echo Correlated Spectroscopic Imaging (TSE-COSI) sequence acquiring multi-voxel based 2D COSY of breast tissues in vivo.