Differentiation Between Brain Metastasis and Glioblastoma Using MRI and Two-Dimensional Turbo Spectroscopic Imaging Data

¹Department of Electrical engineering, Division ESAT-SCD, Katholieke Universiteit Leuven, Leuven, Belgium; ²Istituto per le Applicazioni del Calcolo M. Picone, National Research Council, (IAC-CNR), Bari, Italy; ³Departamento de Qumica-Fsica, Facultad de Qumica, Universidad de Valncia, Valncia, Spain; ⁴CIBER of Bioengineering, Biomaterials and Nanomedicine, ISC-III, Spain
In spite of the significant progresses achieved in the field of MRI in the last decades, the differentiation between brain metastasis and glioblastoma is still a challenge since conventional MRI alone cannot always differentiate the two tumor types, while they require a completely different therapeutic treatment. Previous studies have shown that, in contrast to metastases, the peritumoral region in glioblastomas contains infiltrating tumor cells. This study explores the combination of MRI and two-dimensional Turbo Spectroscopic Imaging to distinguish the aforementioned tumors and proposes a novel classification method based on nosologic images, allowing a visual differentiation between metastasis and glioblastoma lesions.