Accuracy of MRI/3D-MRSI Based TRUS-Biopsy in Peripheral Zone (PZ) and Transition Zone (TZ) of Prostate Gland in Patients Suspected for Cancer with Prior Negative Biopsy

Claudia Testa¹, Raffaele Lodi¹, Caterina Tonon¹, Riccardo Schiavina¹, Giuseppe Martorana¹, Alessandro Franceschelli¹, Antonietta Derrico¹, Romeo Canini¹, Bruno Barbiroli¹

Transrectal ultrasound biopsy (TRUS-biopsy) was performed on regions with abnormal MRI and/or 3D-MRSI for both transition (TZ) and peripheral (PZ) zones in patients suspected for prostate cancer with prior negative biopsy. Successively the relationship between 3D-MRSI and histopathological findings was analyzed. Detection rate of cancer was 40.7%; accuracy of the combination of 3D-MRSI and MRI was 0.768 for PZ and 0.822 for TZ. Flogosis remains the main cause of 3D-MRSI false positive findings (28.8%) while benign prostatic hyperplasia and post inflammatory atrophy resulted substantially negative for 3D-MRSI (2.7% and 5.1% false positive findings respectively).