Evaluation of the Prostate After Treatment with High-Intensity Focussed Ultrasound (HIFU) Therapy Using Whole Prostate Diffusion Weighted Imaging (DWI) Analysis

Alex Chapman¹, Nina Tunariu¹, Veronica Morgan², Nandita Desouza¹

High intensity focussed ultrasound (HIFU) is increasingly being used to treat locally recurrent prostate cancer that has failed primary treatment. Nine patients were studied using a 1.5T Intera MR scanner with an endorectal receiver coil, before, after 6 weeks and after 6 months of HIFU treatment. Standard and diffusion-weighted images were acquired. ADCs and volumes for the whole gland were obtained for all time points. The results are suggesting that ADC at 6 weeks is an indicator of subsequent reduction in PSA. Earlier time points for measuring ADC may prove useful in predicting subsequent outcome and warrant further investigation.