Andrew C.H. Yung1, Jenny C.H. Tso1, Jennifer Flexman1, Sylvia Ng1,2, Donald Yapp1,2, Piotr Kozlowski1
1University of British Columbia, Vancouver, BC, Canada; 2British Columbia Cancer Research Centre
The use of ferumoxide is investigated for use in the blood volume fraction (BV) and vessel size index (VSI) measurements of a xenograft mouse model of pancreatic cancer. The ferumoxide susceptibility contrast remains stable for at least 1.5 hours after injection. Spectroscopy measurements produce a susceptibility value of 1.37 ppm for ferumoxide in blood. BV was well correlated with a histology measure of perfused tumour vessels, and VSI showed good correlation with BV. We show that ferumoxide can be successfully used in BV and VSI measurements.