Xin Li1, Ryan A. Priest2, Faisal Siddiqui3, Tomasz M. Beer4,5, Mark G. Garzotto6,7, William J. Woodward1, William D. Rooney1, Charles S. Springer, Jr. 1
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA; 2Departments of Radiology, Oregon Health & Science University, Portland, OR, USA; 3School of Medicine, Oregon Health & Science University, Portland, OR, USA; 4Departments of Hematology/Oncology, and Urology, Oregon Health & Science University, Portland, OR, USA; 5Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA; 6Portland VA Medical Center, Portland, OR, USA; 7Department of Urology, Oregon Health & Science University, Portland, OR, USA
Dynamic-contrast-enhanced (DCE)-MRI pharmacokinetic modeling usually ignores potential water proton signal reduction due to transverse relaxation effects. Using prostate DCE-MRI data, we investigate a potential transverse relaxation effect on DCE-MRI model parameter values, by using a water exchange (shutter-speed) model along with a simplified factor to account for putative transverse relaxation signal quenching.