Delay and Dispersion Correction for Simultaneous Quantification of Perfusion and Permeability in the Prostate Using DCE-MRI with a Dual-Contrast Sequence

Lutz Ldemann¹, Tobias Franiel², Matthias Taupitz², Hagen Rehbein¹, Dirk Beyersdorff²

Contrast enhancement of the prostate in dynamic MR imaging can be used to assess perfusion and permeability using a low-molecular-weight con-trast medium. The arterial input function is subject to delay and dispersion during its passage from the point of measurement to the tar-get voxel. The dispersion is inherently coupled to the delay. Whereas the delay can easily assessed the bolus dispersion is caused by two proc-esses, the dispersion during its passage from the point of measurement to the tissue and the dispersion by the tissue passage expressed by the mean transit time.