Marko K. Ivancevic1,2, Charles R. Meyer3, Craig J. Galban2, Benjamin A. Hoff2, Thomas C. Kwee2, Brian D. Ross2, Thomas L. Chenevert2
1MRI, Philips Medical Systems, Cleveland, OH, USA; 2Radiology, University of Michigan, Ann Arbor, MI, USA; 3Radiology, University of Michgan, Ann Arbor, MI, USA
Quantitative biomarkers are being developed for tumor therapy response assessment where timely assessment of therapy response is extremely important. Diffusion-weighted MR imaging provides such a biomarker, the apparent diffusion coefficient (ADC) in a noninvasive manner. In order to estimate the accuracy of ADC as a biomarker and provide uniform quality assurance across multiple MR systems a reproducible phantom is needed. In this study ADC was measured in an ice-water phantom on multiple field strength MR scanners.