MR Characterization of Two Experimental Models of Ovarian Cancer: Metabolite Quantification and Diffusion and Perfusion Assessment

Rossella Canese¹, Maria Elena Pisanu¹, Alessandro Ricci¹, Luisa Paris¹, Carmela Rozera¹, Massimo Spada¹, Albino Cesolini¹, Massimo Venditti¹, Massimo Giannini¹, Filippo Belardelli¹, Egidio Iorio¹, Franca Podo¹

Ovary cancer is the gynaecological malignancy at highest death rate. MRI combined with MRS has demonstrated its usefulness in tumour diagnosis, prognosis and treatment evaluation. In this work two models of human ovarian carcinoma were implemented and characterised by quantitative MRS and ADC measurements: 1) sc implantation in the dorsum and 2) ip implantation in the peritoneum of SKOV3ip cells in SCID mice. Both ortho and heterotopic ovarian cancer models gave reasonable values for tCho and Ino concentration as well as for ADCs and perfusion fractions and can represent valuable tools in the evaluation of new therapies.