Yuting Lin1, Mehmet B. Unlu1, Brian Grimmond2, Anup Sood2, Egidijus E. Uzgiris3, Orhan Nalcioglu1, Gultekin Gulsen1
1Center for functional onco imaging, University of California, Irvine, CA, USA; 2GE Global Research, Niskayuna, NY, USA; 3Rensselaer Polytechnic Institute, Troy, NY, USA
Multi-modality imaging is becoming a trend in developing new generation in vivo imaging techniques for diagnosis. Recently, our group has developed a hybrid MRI/DOT multi-modality imaging system. In such a multi-modality system, each modality measures a different parameter set, which make it difficult to cross-validate the parameters measured by different modalities. An alternative solution is using a bi-functional contrast agent that provides contrast for both optical and MRI simultaneously. Here, our in vivo small animal study is the first to validate a true multi-modality system with a true multi-modality contrast agent.