Hiromitsu Onishi1, Tonsok Kim1, Masatoshi Hori1, Takamichi Murakami2, Takahiro Tsuboyama1, Mitsuaki Tatsumi1, Atsushi Nakamoto1, Yasuhiro Nakaya1, Kaname Tomoda1, Hironobu Nakamura1
1Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Department of Radiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
The purpose of the present study was to analyze the kinetics in the uptake of Gd-EOB by the hepatocytes by using a Michaelis-Menten model. Uptake rate and concentration of Gd-EOB was estimated from Gd-EOB-enhanced dynamic MR imaging data. To evaluate whether the relationship between the uptake rate and the Gd-EOB concentration obey Michaelis-Menten kinetics, an Eadie-Hofstee Plot was analyzed. A Hanes-Woolf Plot was also generated to obtain an apparent Michaelis constant.