Abstract #4058

Quantitative Analysis for Diffusion-Weighted and Superparamagnetic Iron Oxide Enhanced Magnetic Resonance Imaging in Patients with Chronic Hepatitis C: Correlation with Pathologic Fibrosis and Inflammatory Scores and Clinical Severity

Kiminori Fujimoto^1,2, Tatsuyuki Tonan¹, Shuji Nagata¹, Sanae Azuma¹, Osamu Nakashima³, Masayoshi Kage³, Takumi Kawaguchi⁴, Naofumi Hayabuchi¹, Koji Okuda⁵, Takeshi Johkoh⁶

¹Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; ²Center for Diagnostic Imaging, Kurume University Hospital, Kurume, Fukuoka, Japan; ³Department of Pathology, Kurume University School of Medicine, Kurume, Japan; ⁴Department of Medicine, Kurume University School of Medicine, Kurume, Japan; ⁵Department of Surgery, Kurume University School of Medicine, Kurume, Japan; ⁶Department of Radiology, Kinki Central Hospital, Itami, Japan

The aim of study was to evaluate mean of region-of-interest and volume histogram analysis of signal intensities obtained by diffusion-weighted (DW)-MRI and superparamagnetic iron oxide (SPIO)-MRI for predicting the histopathologic liver fibrosis and inflammation scores and clinical severity. The study included 34 patients with chronic hepatitis C and 9 patients without hepatic dysfunction were retrospectively evaluated. The quantitative analysis of ADC values (DW-MRI) and reduction percentage of liver-to-muscle signal intensity ratio (SPIO-MRI) is helpful in predicting the histopathologic liver fibrosis as well as clinical severity in patients with chronic hepatitis.