David M. Rouffet1,2, Rachida Fissoune1, Christophe Hautier3, Dominique Sappey-Marinier4, Martine Laville5, Danielle Ibarolla4, Monique Sothier5, Marie-France Monnet6, Michel Ovize6, Marc Bonnefoy7, Chris Boesch8, Emmanuelle Canet-Soulas1
1CREATIS LRMN, UMR CNRS #5220, INSERM U630, University of Lyon - Universit Lyon 1, Lyon, Rhone-Alpes, France; 2Centre for Ageing, Rehabilitation Exercise & Sport, Victoria University , Melbourne, Victoria, Australia; 3CRIS EA647, University of Lyon - Universit Lyon 1, France; 4CERMEP, University of Lyon - Universit Lyon 1, France; 5CRNH, University of Lyon - Universit Lyon 1, France; 6Unit de Rducation Cardiaque, University of Lyon - Universit Lyon 1, France; 7Service de Mdecine Griatrique, University of Lyon - Universit Lyon 1, France; 8Dept.Clinical Research, University Bern, Switzerland
Epidemiological studies show that impairments of the insulin-stimulated glucose metabolism in skeletal muscle initiate type 2 diabetes apparition in elderly subjects. Repeating physical activities throughout entire life may positively affect insulin sensitivity by improving intracellular fat homeostasis in skeletal muscle. 1H nuclear magnetic resonance spectroscopy (1H-MRS) technique offers the possibility to study lipid metabolism by performing repeated and non invasive measurements of intramyocellular lipids (IMCL) content. The objective of this study was to determine if the exercise-induced IMCL mobilization is related to physical activity, maximal aerobic capacity and insulin sensitivity in elderly people.