Jose G. Raya1, Gerd Melkus2, Olaf Dietrich, Silvia Adam-Neumair3, Elisabeth Mtzel4, Maimilian F. Reiser5, Peter Jakob2, Christian Glaser4
1Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, Universisty of Munich, Munich, Germany; 2University of Wrzburg, Germany; 3Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, University of Munich; 4University of Munich, Germany; 5Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, University of Munich, Germany
A large collective of samples of patellar cartilage (n=38 healthy, n=11 moderate osteoarthritis (OA) and n=7 severe OA) have been multiparametric analyzed at 17.6T. For each sample maps of T2, T1, ADC, FA and water fraction volume (WFV) were obtained. After imaging, samples underwent histology and proteoglycans were stained with safraninO. A progressive loss of the tangential zone with OA grade is observed in MR, This coincides with the continuous proteoglycan loss from the articular surface observed in histological sections. Increased ADC, T1 and WVF were found in regions with low proteoglycans. FA does not depended on proteoglycan content.