Ping-Huei Tsai1, Ming-Chung Chou2, Ming-Huang Lin3, Chien-Yuan Lin3, Hsiao-Wen Chung1, Heng-Sheng Lee4, Guo-Shu Huang2
1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan; 3Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan; 4Department of Pathology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
The purpose of this study is to investigate the relationship between the HA treatment and articular cartilage T2 in a rat model of OA by MR quantitative measurements. Our preliminary findings suggest that HA treatment may prevent the degradation of knee cartilage and has a potential to promote the regeneration on the OA knee, which is observable by longitudinal quantitative MR T2 measurements as shown in the slowdown of the tendency of increasing T2 value.