Blood-Pool Imaging Properties of Non Protein-Binding Extracellular Unspecific Gadolinium-Based Contrast Media

Patrick Asbach¹, Moritz Wagner¹, Matthias Rief¹, Matthias Taupitz¹, Bernd Hamm¹, Christian Klessen¹

The aim of the study was to investigate whether non protein-binding extracellular unspecific Gadolinium-based contrast media have a blood-pool effect that allows equilibrium phase MR angiography. 30 patients received either a protein-binding blood-pool contrast medium or a non protein-binding unspecific extracellular contrast medium. Quantitative signal intensity measurements and qualitative grading of vessel contrast were performed. Imaging was carried out up to 25 minutes after contrast injection. Non protein-binding unspecific extracellular Gadolinium-based contrast media have the potential of blood pool phase imaging within a time window of less than 15 minutes.