Kyle Stephan McCommis1, Robert O'Conner1, Dana R. Abendschein2, Bernd Misselwitz3, Robert J. Gropler1, Jie Zheng1
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; 2Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA; 3Bayer Schering Pharma AG, Berlin, Germany
A new T2 preparation sequence was developed to calculate myocardial oxygenation at rest and during pharmacologic hyperemia. Imaging was performed in normal dogs, as well as dogs with severe coronary stenosis. Myocardial oxygen extraction fraction and oxygen consumption were measured using these techniques and the results were compared with the established turbo-spin-echo method. Consistent findings were observed and the sensitivity of the oxygenation measurement was significantly improved using the new sequence, likely due to fewer flow artifacts.