Jordin Daniel Green1,2, Matthias Voehringer2, Jacqueline A. Flewitt2, Sven Zuehlsdorff3, John Victor Tyberg2, Matthias G. Friedrich2
1Siemens Healthcare, Calgary, Alberta, Canada; 2University of Calgary, Calgary, Alberta, Canada; 3Siemens Medical Solutions USA, Inc., Chicago, IL, USA
The purpose of this study was to demonstrate that BOLD-sensitive cine-EPI with effective TE=15 ms could detect changes in myocardial oxygenation. We developed a cine-EPI sequence and tested it in dogs with varying degrees of coronary artery stenoses, at rest and during adenosine infusion. We detected statistically significant differences in the response to adenosine in myocardial territories affected by high-grade stenoses compared to territories in the same dog unaffected by the high-grade stenoses.