Yeun-Chung Chang1, Ang Yuan2, Yi-Chien Lu3,4, Jyh-Horng Chen4, Pan-Chyr Yang2
1Department of Medical Imaging, National Taiwan University Hospital , Taipei, Taiwan; 2Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 4Interdisciplinary MRI/MRS Lab, Department of Electric Engineering, National Taiwan University, Taipei, Taiwan
This study is to evaluate the feasibility of dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) in subcutaneously transplanted vascular endothelial growth factor (VEGF) overexpressing NSCLC in a severe combined immunodeficiency (SCID) mice model. Tumor growth accompanied with increased vascularity characterized with higher Ktrans and Kep, values indicating increased transfer constant due to vascular permeability. Perfusion MRI study is feasible for evaluating NSCLC with VEGF overexpressing transgenic SCID mice model. This study enables the future implementation of DCE perfusion MRI study in SCID mice model of lung cancer.