Paul Smeets1,2, Pascalle Weijzen2, Cees de Graaf2, Max Viergever1
1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
Satiation is brought about by a combination of sensory and metabolic factors.We investigated the effects of sip size (small large) and energy content (Energy No Energy) on taste activation by scanning subjects before and after ingestion of 450mL orangeade using fMRI. Energy content affected brain activation associated with tasting orangeade before, but not after, treatment in the amygdala, striatum and inferior temporal gyrus. Sip size had no significant effects. Our results show that the brain can distinguish between caloric and non-caloric beverages and suggest that sensory and metabolic satiation differentially affect taste activation.