Halima Chahboune1, Caroline Chua2, Praveen Ballabh2,3, Fahmeed Hyder4,5
1Diagnostic Radiology , Yale University School of Medicine , New HAven, CT, USA; 2Pediatrics, New York Medical College - Westchester Medical Center, Valhalla, NY, USA; 3Cell Biology, New York Medical College - Westchester Medical Center, Valhalla, NY, USA; 4Diagnostic Radiology, Yale University School of Medicine, New HAven, CT, USA; 5Biomedical Engineering, Yale University School of Medicine , New HAven, CT, USA
DTI is used as a noninvasive diagnostic marker to characterize perinatal brain injury in animal model. The goal of this study was to use ex vivo DTI to evaluate the long-term consequences of germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) in rabbit pup. This study shows injury to the corpus callosum, corona radiate and fimbria fornicis caused by GMH-IVH. This injury to white matter is in agreement with histological and neurobehavioral evaluation. These results in the GMH-IVH model are important for understanding neurodevelopmental difficulties found in low birth weight preterm infant, and evaluate strategies in prevention and/or treatment of post-hemorrhagic complications