Abstract #3441

J-Difference Editing Method to Evaluate GABA May Reveal the Mechanism of ACTH Therapy for Infantile Spasms as a Useful Predict Biomarker.

Ayumi Nose¹, Masafumi Harada², Hitoshi Kubo², Kenji Mori³, Tsuyoshi Matsuda⁴, Hiromu Nishitani¹

¹Radiology, University of Tokushima, Tokushima, Japan; ²Medical Imaging, University of Tokushima, Tokushima, Japan; ³Pediatrics, University of Tokushima, Tokushima, Japan; ⁴Imaging Application Tech Center,GE Yokokawa Medical Systems, Tokyo, Japan

Adrenocorticotropic hormone (ACTH) therapy has been used for rapid and complete elimination of infantile spasms (West syndrome) which is one of intractable epilepsies. The purposes of this study were to evaluate the metabolic changes including GABA before and after ACTH administration for infantile spasms, and to find a useful biomarkers to predict efficacy of ACTH therapy.