Martin Kavec1, Mathieu Vokaer2, Danielle Balriaux1
1Neuroradiology, Erasme Hospital, Brussels,
Belgium; 2Neurology, Erasme Hospital, Brussels, Belgium
The present data suggest that along the healthy aging, large areas of
associative cortices may lose shape and compactness. These changes take place
predominately in the left hemisphere. In the MS subjects on the other hand, the
local gyrification index increased with disability in a several areas of
associative cortices. These areas were larger and distinct from those suffering
from MS related cortical atrophy. Therefore, local gyrification index may
possibly probe for processes of an early irreversible axonal damage, and thus
bring more insight into pathology of MS.