Hagen H. Kitzler1, Sean C. Deoni2,3, Cyndi Harper-Little1, Andrew Leung4, Marcelo Kremenchutzky5, Brian K. Rutt1
1Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; 2Centre for Neuroimaging Research, Institute of Psychiatry, King's College London, London, UK; 3Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford, UK; 4Department of Diagnostic Radiology and Nuclear Medicine, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada; 5Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
This study used a novel quantitative myelin-sensitive MR imaging method known as multi-component Driven Equilibrium Single Pulse Observation (mcDESPOT) to explore changes in Normal Appearing White Matter (NAWM) in early and late stages of MS development. The exploration of comparative histogram and ROI analyses of the myelin volume fraction (VFM) a parameter derived by mcDESPOT data processing revealed a promising trend towards a correlation of the measured VFM with the stage of disease development and clinical disability in a spectrum of different types of MS.