Vt Herynek1,2, Emil Pollert3, Pavla Jendelov2,4, Ondej Kaman3,5, Miroslav Veverka3, Pavel Veverka3, Eva Sykov2,4, Milan Hjek2,6
1Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2Center for Cell Therapy and Tissue Repair, Second Medical Faculty, Charles University, Prague, Czech Republic; 3Institute of Physics, ASCR, Prague, Czech Republic; 4Institute of Experimental Medicine, ASCR, Prague, Czech Republic; 5Faculty of Science, Charles University, Prague, Czech Republic; 6Department of Radiodiagnostic and Interventional Radiology,, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
We have synthesized, physically characterized and tested coated ferromagnetic manganese perovskite particles. SiO2 coating minimizes toxicity in cell cultures and the particles can be used as cellular labels for guided termoablation. Ferromagnetic particles can be heated by external high frequency electromagnetic field. Thermoablation is self-controlled due to low Curie temperature, the material cannot be heated to temperature over Tc.