In Vivo Targeting of α ν β 3-Specific Dual-Modality Micellar Nanoprobes

Chase W. Kessinger¹, Osamu Togao¹, Chalermchai Khemtong¹, Masaya Takahashi¹, Jinming Gao¹

Here we report an α _vb₃-specific dual-imaging magnetofluorescent nanoprobes that allowed detection of angiogenic tumor vessels by both fluorescent and magnetic resonance imaging. The α _vb ₃-targeting specificity and temporal tumor accumulation profiles were demonstrated in a human lung tumor xenograft model in nude mice in vivo.