Jullie W. Pan1,2, Ruben Kuzniecky3, Susan Spencer4, Dennis Spencer1, Hoby P. Hetherington1,5
1Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; 2BME, Yale University School of Medicine, New Haven, CT, USA; 3Neurology, New York University School of Medicine, New York, NY, USA; 4Neurology, Yale University School of Medicine, New Haven, CT, USA; 5Radiology, Yale University School of Medicine, New Haven, CT, USA
While resting fMRI connectivity studies have linked the thalamus and hippocampus in humans, whether such connectivity maps are manifest metabolically is unknown. Our goal is to establish the presence of such a network through 1H spectroscopic imaging data. We use 1H MRSI data from a subcortical set of loci with a common factor analysis to assess for metabolic connectivity in controls and epilepsy patients. Not only is the subcortical network readily detected in resting connectivity studies, it is important to evaluate this system in epilepsy as it may be thought to participate in nearly all seizures and epilepsy types.