Registration Methodology of Histology with in Vivo 3T MRI for Human Prostate

Hyunjin Park¹, Morand Piert¹, Bing Ma¹, Charles Meyer¹

Registration of histology and in vivo MRI is an important problem as registered histology onto the in vivo MRI enables pixel by pixel comparison of in vivo MRI imaging features with ground truth of ex vivo histology. For human prostate, registration of histology and in vivo MRI is a difficult as the prostate undergoes a complex set of deformations. A methodology has been proposed to register various in vivo scans with histology for human prostate. Here we have refined and applied the methodology to in vivo 3T diffusion MRI for two cases.