Ryan Chamberlain1, Tom M. Wengenack2, Joseph F. Poduslo2, Clifford R. Jack3, Michael Garwood1
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; 2Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA; 3Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA
High-resolution 3D imaging of amyloid plaques in transgenic mouse models of Alzheimer's disease has previously been performed using Cartesian k-space sampling. This work investigates cylindrical k-space sampling methods. The k-space data points are still collected on a Cartesian grid, but they are contained within a cylinder instead of a box. The cylindrical methods provide a rotationally invariant point spread function, and they improve the contrast-to-noise ratio of the plaques for a give scan time.