Brain Capillary Water Permeability from Proton Density 1H2O Imaging in the Rat During Deuterated Saline Bolus Passage

Audrey H. Selzer¹, William D. Rooney¹, Thomas M. Barbara¹, James A. Goodman¹, Charles S. Springer Jr. ¹, Xin Li¹

In vivo intercompartmental water exchange has been studied extensively using labeled water. Here we use proton imaging to monitor the ²HOH concentration change during a bolus injection of deuterated saline solution, and thence measure non-equilibrium transendothelial water transport. This provides a direct comparison of MRI results of water transport with those from other methods.