T2 Correction and Quantitation Method on Highly Resolved 2D Constant Time 1H Spectra in Human Brain Using 2D FT of Shared Time Domain Data

Hidehiro Watanabe¹, Nobuhiro Takaya¹, Fumiyuki Mitsumori¹

A T₂ correction and quantitation method on CT-PRESS spectra using 2D FT of shared time domain data is proposed. Spectra with varied T_ct are generated by reconstruction of several parts of the total time domain data. Then, T₂ is calculated by curve-fitting of peak volumes on those spectra. Coil-loading factors were considered by the internal water reference method for quantitation. T₂ of a Cr singlet calculated by this method was in good agreement with T₂ by the conventional 1D method. After quantitation protocol, concentration of glutamate was calculated as 8.0 mM which is in good agreement with reported values.