Nelly A. Volland1, Thomas H. Mareci2,3, Nicholas E. Simpson4,5
1Biomedical Engineering, University of Florida, Gainesville, FL, USA; 2Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA; 3National High Magnetic Field Laboratory, University of Florida, Gainesville, FL, USA; 4Medicine, University of Florida, Gainesville, FL, USA; 5McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Introduction: Non-invasive in vivo imaging and spectroscopy of a bioartificial pancreas using an implantable inductively-coupled coil system at 11.1T is discussed. Methods: An implantable coil was constructed, coated, integrated with the macroconstruct, and implanted in a mouse peritoneal cavity. The coil-construct assembly was inductively-coupled to an external coil and tested in vivo. Results: In vivo studies showed sensitivity improvement of 2.35 over a surface coil when the average distance between the two coils was 0.64cm. Choline spectra, 19F images and spectra were also acquired. Conclusion: An implantable system was successfully tested and used to monitor a bioartificial pancreas in vivo.