Synthesis and Characterization CRGD-PEG Iron Oxide Nanoparticles of Noninvasive Imaging for Targeting α vβ 3Integrins by MRI

¹Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; ²Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

The fabrication and characterization of PEG-coated magnetic nanoparticles, SPIO-mPEG-cRGD as nanoprobes for MR imaging to target specific receptors were reported. From the results, we found that the SPIO-mPEG-cRGD had well-dispersed in different pH value solutions, low protein absorption from medium, no hysteresis, high saturation magnetization and low cytotoxicity of different cells. Moreover, SPIO-mPEG-cRGD had ability to target the MCF-7, HT-29, A549, and HT-1080 cells proved by in vitro and in vivo MR imaging studies.