Kate W. Jordan1, Christen B. Adkins1, Li Su2, Eugene J. Mark1, David C. Christiani2,3, Leo L. Cheng1,4
1Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; 2Environmental Health, Harvard School of Public Health, Boston, MA; 3Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; 4Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA
With the urgent clinical need for early diagnosis of lung cancer, this project aims to develop a blood serum-based metabolomic screening test that may provide biochemical information indicating the risk of lung cancer and direct patients to further radiological tests for disease detection at clinically asymptomatic stages. Human SCC and adenocarcinoma tissue and serum paired samples from 14 patients, and seven serum samples from healthy controls, were analyzed by high-resolution magic angle spinning MRS. The spectra of tissue and sera showed differentiating capabilities between two cancer types and healthy controls, indicating the potential to assess risk of lung cancer.