Deirdre Maria McGrath1, Roxana M. Vlad2, Warren D. Foltz1, Kristy K. Brock1,3
1Radiation Medicine Program, Princess Margaret Hospital, University Health Network,, Toronto, Ontario, Canada; 2Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada; 3Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
Histology provides the gold standard for tumor delineation and the assessment of tumor response to cancer treatment. There is a growing role for multi-modality image registration with histology in radiotherapy in order to estimate the anatomical changes during and following radiotherapy. However, fixation and pathology techniques change tissue properties non-uniformly and the margins of the tissue sections are often distorted and sometimes disrupted. Furthermore, differences in sectioning angle and thickness increase the difficulty of correlating cross-sectional imaging and pathological findings. We present preliminary results of testing two injectable fiducial markers for whole-specimen histopatholoy correlation with high-field (7T) MR imaging.