Colleen Bailey1,2, Anoja Giles1,3, Gregory J. Czarnota1,3, Greg J. Stanisz1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Acute myeloid leukemia cells were treated with cisplatin to induce apoptosis. Diffusion MRI at a range of b-values yielded apparent diffusion coefficients that were not significantly different from controls at early stages of apoptosis, but were significantly higher at late stages. These changes cannot be fully accounted for by increased extracellular water and volume fractions. A component of the increase may be due to altered cell shape from membrane blebbing.