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Abstract #2220

Multinuclear and Multiparametric MR Imaging as an Early Treatment Response Biomarker for Preoperative Systemic Therapy in Breast Cancer:Preliminary Results

Michael A. Jacobs1,2, Ronald Ouwekerk3, Antonio C. Wolff4, Vered Stearns4, Katarzyna Macura3, Ihab Kamel3, Zaver M. Bhujwalla2,3, David Bluemke3

1The Russell H. Morgan Department of Radiology and Radiological Science , The Johns Hopkins University School of Medicine, Baltimore , MD , USA; 2Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore , MD , USA; 3The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; 4Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA


Combined proton (1H) imaging and sodium (23Na) imaging will provide a comprehensive description of the tumor microenvironment in order to assess response to therapy in operable breast cancer in order to predict therapeutic response.