KiaRash Emami1, Masaru Ishii1,2, Stephen Kadlecek1, John MacDuffie-Woodburn1, Jianliang Zhu3, Stephen Pickup1, Jiangsheng Yu1, Matthew Stetz1, Michael Stephen4, Rahim Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA; 3Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA, USA; 4Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
The dead space volume in measurements of lung ventilation using gaseous contrast agents can be a substantial source of error if their magnitude is not carefully incorporated in the gas distribution model. This work presents a three-compartment model to include both static and dynamic dead volumes of the ventilation and pulmonary system and to correct for their effects in regional measurements of lung ventilation using hyperpolarized 3He MRI.