Shigeo Okuda1, Koichi Oshio1, Akihiro Tanimoto1, Hironori Asada2, Masahiro Jinzaki1, Ayano Akita1, Hirotaka Akita1, Tomonori Hada3, Masataka Furuya4, Hiroshi Shinmoto5, Yasunori Yoshimura4, Sachio Kuribayashi1
1Department of Diagnostic Radiology, Keio University School of Medicine, Shinjyuku-ku, Tokyo, Japan; 2Department of Obstetrics and Gynecology, Keio University School of Medicine, TokyoTokyo, Japan; 3Department of Obstetrics and Gynecology, Keio University School of Medicine, Japan; 4Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan; 5Department of Radiology, National Defense Medical College, Saitama, Japan
The purpose of our study is to assess vascular bed volume change of uterine fibroids after GnRHa treatment by using Gadolinium-enhanced dynamic R2* imaging (R2*I). Double-echo fast SPGR sequence was utilized to generate R2*I. A total of 25 patients was assessed with R2*I before and after the treatment. We measured area-under-the-curve (AUC) of signal intensity curve in selected ROI (3x3 cm) on R2*I, and compared AUCs of the first and second examinations. Although increase of AUC value was observed in four patients, the mean values of AUC were decreased from 40.2 to 19.0 with significant difference (p<.0001, paired t test).