Andreas Markus Hoetker1, Peter Mildenberger1, Theo Junginger2, Christoph Dueber3, Torsten Hansen4, Matthias Menig5, Andreas Pohlmann, Achim Heintz6, Katja Oberholzer3
1Klinik und Poliklinik fr diagnostische und interventionelle Radiologie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; 2Klinik und Poliklinik fr Allgemein- und Abdominalchirurgie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; 3Klinik und Poliklinik fr diagnostische und interventionelle Radiologie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; 4Institut fr Pathologie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; 5Klinik und Poliklinik fr Radioonkologie sowie Strahlentherapie, Klinikum der Johannes- Gutenberg Universitt Mainz, Mainz, Germany; 6Klinik fr Allgemein-, Viszeral- und minimalinvasive Chirurgie, St. Hildegardis Krankenhaus, Mainz, Germany
To assess the therapeutic effects of neoadjuvant radio-chemotherapy on tumor microcirculation DCE- MRI parameters were measured in patients with rectum carcinoma using two slices in maximal tumor extent per patient and measurement. The results of these different models (Brix/Tofts) were compared between each other and the different slices and showed, that the slice selection did not affect later analysis and that it was not possible to find a relevant difference in therapeutic effects between the corresponding parameters of the pharmacokinetic models.